When less may be more: calorie restriction and response to cancer therapy

BMC Medicine

Minireview

Shannon B. McDonell¹  Laura A. Smith¹  Ciara H. O’Flanagan¹  Stephen D. Hursting² 

[1] Department of Nutrition, University of North Carolina, 27517, Chapel Hill, NC, USA;Department of Nutrition, University of North Carolina, 27517, Chapel Hill, NC, USA;Lineberger Comprehensive Cancer Center, University of North Carolina, 27517, Chapel Hill, NC, USA;Nutrition Research Institute, University of North Carolina, 28081, Kannapolis, NC, USA;Department of Nutrition, University of North Carolina at Chapel Hill, 2100 Michael Hooker Research Center, Campus Box 7461, 27599, Chapel Hill, NC, USA;

关键词: Calorie restriction;    Chemotherapy;    Radiation therapy;    Ketogenic diet;    Fasting;    Metabolism;    Autophagy;    Cachexia;    Insulin-like growth factor 1;    Drug resistance;   

DOI  :  10.1186/s12916-017-0873-x

 received in 2016-12-22, accepted in 2017-05-15,  发布年份 2017

来源: Springer

【 摘 要 】

Calorie restriction (CR) extends lifespan and has been shown to reduce age-related diseases including cancer, diabetes, and cardiovascular and neurodegenerative diseases in experimental models. Recent translational studies have tested the potential of CR or CR mimetics as adjuvant therapies to enhance the efficacy of chemotherapy, radiation therapy, and novel immunotherapies. Chronic CR is challenging to employ in cancer patients, and therefore intermittent fasting, CR mimetic drugs, or alternative diets (such as a ketogenic diet), may be more suitable. Intermittent fasting has been shown to enhance treatment with both chemotherapy and radiation therapy. CR and fasting elicit different responses in normal and cancer cells, and reduce certain side effects of cytotoxic therapy. Findings from preclinical studies of CR mimetic drugs and other dietary interventions, such as the ketogenic diet, are promising for improving the efficacy of anticancer therapies and reducing the side effects of cytotoxic treatments. Current and future clinical studies will inform on which cancers, and at which stage of the cancer process, CR, fasting, or CR mimetic regimens will prove most effective.

【 授权许可】

CC BY   
© The Author(s). 2017