Oridonin prevents insulin resistance–mediated cognitive disorder through PTEN/Akt pathway and autophagy in minimal hepatic encephalopathy

Journal of Cellular and Molecular Medicine

Weishan Zhuge¹  Qichuan Zhuge²  Ruimin You³  Saidan Ding³  Xiaoai Lu³  Leping Liu³  Fangfang Wen⁴  Jian Wang⁴ 

[1] Gastrointestinal Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China;Neurosurgery Department, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China;Zhejiang Provincial Key Laboratory of Aging and Neurological Disease Research, Department of Surgery Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China;Zhejiang Provincial Key Laboratory of Aging and Neurological Disease Research, Department of Surgery Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China;Key Laboratory of Diagnosis and Treatment of Severe Hepato‐Pancreatic Diseases of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China;

关键词: autophagy;    cognitive;    insulin resistance;    minimal hepatic encephalopathy;    oridonin;    synaptic;   

DOI  :  10.1111/jcmm.14546

来源: Wiley

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