Bioenergetic and inflammatory systemic phenotypes in Alzheimer’s disease APOE ε4‐carriers

Aging Cell

Nanda K. Yellapu¹  Dong Pei¹  Prabhakar Chalise¹  Jeffrey M. Burns²  Xiaowan Wang²  Heather M. Wilkins³  Russell H. Swerdlow⁴  Rebecca Bothwell⁵  Heidi Anderson⁵  Erin Schwartz⁵  Annette M. Becker⁵  Blaise W. Menta⁶  Scott J. Koppel⁷  Cynthia M. Gouvion⁸  Mohammad Haeri⁸ 

[1]Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, KS, USA

[2]Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA

[3]University of Kansas Alzheimer's Disease Center, Kansas City, KS, USA

[4]Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA

[5]University of Kansas Alzheimer's Disease Center, Kansas City, KS, USA

[6]Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS, USA

[7]Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA

[8]University of Kansas Alzheimer's Disease Center, Kansas City, KS, USA

[9]Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS, USA

[10]Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA

[11]University of Kansas Alzheimer's Disease Center, Kansas City, KS, USA

[12]University of Kansas Alzheimer's Disease Center, Kansas City, KS, USA

[13]Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS, USA

[14]University of Kansas Alzheimer's Disease Center, Kansas City, KS, USA

[15]Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA

[16]University of Kansas Alzheimer's Disease Center, Kansas City, KS, USA

[17]Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA

关键词: Alzheimer's disease;    APOE;    bioenergetics;    inflammation;    mitochondria;   

DOI  :  10.1111/acel.13356

来源: Wiley

【 授权许可】

CC BY