Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila

eLife

Anton Miroschnikow¹  Andreas Schoofs¹  Ingo Zinke¹  Michael J Pankratz¹  Sebastian Hückesfeld¹  Philipp Schlegel²  Richard D Fetter³  Casey M Schneider-Mizell³  James W Truman³  Albert Cardona⁴  André N Haubrich⁵ 

[1] Department of Molecular Brain Physiology and Behavior, LIMES Institute, University of Bonn, Bonn, Germany;Department of Zoology, University of Cambridge, Cambridge, United Kingdom;Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States;Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States;MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge, United Kingdom;Department of Physiology, Development and Neuroscience, Cambridge, United Kingdom;Life & Brain, Institute for Experimental Epileptology and Cognition Research, University of Bonn Medical Center Germany, Bonn, Germany;

关键词: neuroendocrine system;    connectome;    sensory synapses;    carbon dioxide;    interneuron;    neuropeptides;    D. melanogaster;   

DOI  :  10.7554/eLife.65745

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Neuroendocrine systems in animals maintain organismal homeostasis and regulate stress response. Although a great deal of work has been done on the neuropeptides and hormones that are released and act on target organs in the periphery, the synaptic inputs onto these neuroendocrine outputs in the brain are less well understood. Here, we use the transmission electron microscopy reconstruction of a whole central nervous system in the Drosophila larva to elucidate the sensory pathways and the interneurons that provide synaptic input to the neurosecretory cells projecting to the endocrine organs. Predicted by network modeling, we also identify a new carbon dioxide-responsive network that acts on a specific set of neurosecretory cells and that includes those expressing corazonin (Crz) and diuretic hormone 44 (Dh44) neuropeptides. Our analysis reveals a neuronal network architecture for combinatorial action based on sensory and interneuronal pathways that converge onto distinct combinations of neuroendocrine outputs.

【 授权许可】

CC BY