The Local Neuropeptide System of Keratinocytes

Biomedicines

Nicola Cirillo¹ 

[1] Melbourne Dental School, University of Melbourne, 720 Swanson Street, Carlton, Melbourne, VIC 3053, Australia;

关键词: keratinocytes;    neuropeptides;    hypothalamic-pituitary-adrenal axis;    hypothalamic–pituitary–thyroid axis;    neuroendocrine system;   

DOI  :  10.3390/biomedicines9121854

来源: DOAJ

【 摘 要 】

Neuropeptides have been known for over 50 years as chemical signals in the brain. However, it is now well established that the synthesis of this class of peptides is not restricted to neurons. For example, human skin not only expresses several functional receptors for neuropeptides but, also, can serve as a local source of neuroactive molecules such as corticotropin-releasing hormone, melanocortins, and β-endorphin. In contrast, an equivalent of the hypothalamic-pituitary axis in the oral mucosa has not been well characterized to date. In view of the differences in the morphology and function of oral mucosal and skin cells, in this review I surveyed the existing evidence for a local synthesis of hypothalamic-pituitary, opiate, neurohypophyseal, and neuroendocrine neuropeptides in both epidermal and oral keratinocytes.

【 授权许可】

Unknown