Phytochemical Investigation and Anti-angiogenic Examination of Iraqi Vigna radiata L. Seeds and Sprouts

Iraqi Journal of Pharmaceutical Sciences

ARTICLE

Rabab H. Qassim¹  Enas J. Kadhem¹ 

[1] Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Baghdad

关键词: Vigna radiata;    vitexin;    isovitexin;    high performance thin layer chromatography HPTLC.;   

DOI  :  10.31351/vol29iss2pp37-47

学科分类：计算机网络和通讯

来源: College of Pharmacy University of Baghdad

【 摘 要 】

The plant Vigna radiata L. which belongs to Fabaceae family and known mung bean with characteristic greenish seeds. It was cultivated in Iraq in Al-Nasiriya city. Literature survey available so far revealed there was no studies about Iraqi Vigna radiata plant and its antiangiogenic activity, therefore the objective of this study was to investigate the phytochemical constituents of two different parts of Vigna radiata (seeds and sprouts), and identify their antiangiogenic activity .The flavonoids were isolated by preparative layer chromatography and subjected to different physio-chemical and spectral analytical techniques to identify their chemical structure; rat aorta anti-angiogenesis assay was conducted for both n-butanol fraction of seeds and sprouts. The results showed that two flavonoids (vitexin and isovitexin) were isolated in pure form, both n-butanol fraction of seeds and sprouts have antiangiogenic activity, but sprout extract showed highest blood vessels inhibition in comparison with seeds extract. In conclusion, the difference of Antiangiogenic activity may be related to variation of concentration of bioactive constituents or appearance of new bioactive constituents during germination.

【 授权许可】

CC BY