Sedative and anxiolytic effects of methanolic extract from the leaves of Passiflora actinia

Brazilian Archives of Biology and Technology

Kely Cristina Dos Santos²  Stella Maris Tessaro Figura Kurtz²  Simony Davet Müller¹  Maique Weber Biavatti¹  Rúbia Maria Monteiro Weffort De Oliveira¹  Cid Aimbiré De Moraes Santos² 

[1] ,Universidade Federal do Paraná Departamento de Farmácia Laboratório de FarmacognosiaCuritiba PR ,Brasil

关键词: Anxiolytic;    sedative;    isovitexin;    Passiflora actinia;    Passifloraceae;   

DOI  :  10.1590/S1516-89132006000500005

来源: SciELO

【 摘 要 】

Leaves from several Passiflora species are largely employed in the Brazilian folk medicine as anxiolytic and sedative. In this work the anxiolytic, sedative-like properties and liquid chromatography analysis of methanolic extract of Passiflora actinia were evaluated. The methanol extract and all of its fractions presented significant sedative-like effect in elevated plus-maze and open field tests. Only the aqueous fraction of the methanol extract showed selective anxiolytic activity (30 mg/kg). Chromatographic analysis of the active fractions showed the presence of isovitexin and absence of the classical Passiflora beta-carboline alkaloids or flavonoids such as vitexin, rutin, swertisin, hesperidin and orientin. The tincture obtained from P. actinia leaves presented 0.27 mg/ml of isovitexin and absence of vitexin.

【 授权许可】

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