Antiproliferative Activity of Ethanolic Extract of Ciplukan Herbs (Physalis angulata L.) on 7,12-Dimethylbenz[A]Nthracene-Induced Rat Mammary Carcinogenesis

ISCC (Indonesian Journal of Cancer Chemoprevention)

ARTICLE

Ameilinda Monikawati¹  Sofa Farida¹  Laras Widawaty Putri¹  Yurista Gilang Ikhtiarsyah¹  Edy Meiyanto¹ 

[1]Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada

关键词: Physalis angulata;    breast cancer;    7;    12-dimethylbenz[a]nthracene;    carcinogenesis;    antiproliferative;   

DOI  :  10.14499/indonesianjcanchemoprev2iss2pp228-233

学科分类：药学

来源: Indonesian Society for Cancer Chemoprevention

【 摘 要 】

Physalis angulata L. is an annual herb widely used as popular medicine for the treatment of cancer. Physalis angulata L. ethanolic extract (PEE) has been demonstrated to have strong cytotoxic activity against breast cancer, inhibited cancer cell’s proliferation and induced cell cycle arrest. The aim of our study is to investigate the effect of PEE as a cancer chemopreventive agent on 7,12-dimethylbenz[ a ]nthracene (DMBA)-induced rats mammary. The antiproliferative activity was characterized by monitoring the histopatology representation and expression of cell proliferation on DMBA-induced mammary rats that were treated with PEE against control groups. The histopatology representation were analyzed by Haematoksilin Eosin (HE) staining method, while proliferative activity was detected by AgNOR method. The HE staining results showed significant differences in cells morphology of treatment groups compared to the control groups. Thus results suggest that PEE was able to repair morphology of cells undergoing carcinogenesis. AgNOR method showed decreasing occurrence of black dots between treatment and control groups. Thus, we conclude that PEE has an antiproliferative activity on DMBA-induced rat mammary. Therefore, the ethanolic extract of Physalis angulata herbs is a potential chemopreventive agent on cancer. Further study on its molecular mechanism needs to be explored.

【 授权许可】

CC BY-NC