Basic and Clinical Neuroscience | |
Diagnostic Challenges and Prospects Associated With Zoonotic Tuberculosis of Central Nervous System | |
ARTICLE | |
R. Bapat, Prachi1  D. Shekhawat, Seema1  A. Husain, Aliabbas1  S. Dodkey, Renuka1  F. Daginawala, Hatim1  K. Singh, Lokendra1  S. Kashyap, Rajpal1  | |
[1] Research Centre, Central India Institute of Medical Sciences | |
关键词: Duplex PCR; Mycobacterium Bovis; Tuberculous meningitis; Zoonoses; | |
DOI : 10.32598/bcn.9.10.11.5.803.3 | |
来源: Iran University of Medical Sciences | |
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【 摘 要 】
Introduction: The diagnosis of Tuberculous Meningitis (TBM) has remained a challenge due to its insidious onset and the failure of conventional diagnostic tests. The present study aimed to identify the mycobacterial pathogen in the CSF of patients with TBM and a poor prognosis. Methods: We retrospectively recruited 224 TBM and 34 non-TBM patients admitted to the Central India Institute of Medical Sciences, Nagpur, India, in 2014. The CSF samples of these patients were subjected to a duplex PCR assay for the species-specific identification of the causative pathogen. Results: M. bovis and infection with M.tuberculosis were detected in 7% (18) and 32.9% (85) of the patients, respectively. Moreover, 14% (36) of the study samples were culture positive; however, the mycobacterial pathogens could not be differentiated to the species level. Conclusion: The present study findings emphasized the potentially vital importance of M. bovis identification for appropriate patient management. The obtained data also demonstrated the persistent significance of M. bovis, as a zoonotic pathogen.
【 授权许可】
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