Primary Hyperoxaluria: A Case Report and Review of the Literature

Journal of Comprehensive Pediatrics

ARTICLE

Khoddami, Maliheh¹  Esfandiar, Nasrin³  Kazemi Aghdam, Maryam¹ 

[1] Pediatric Pathology Research Center, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences;Department of Pathology, Medical School, Shahid Beheshti University of Medical Sciences;Pediatric Nephrology Research Center, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences

关键词: Kidney;    Nephropathy;    Crystal;    Calcium Oxalate;   

DOI  :  10.5812/compreped.44085

来源: Kowsarmedical

【 摘 要 】

Oxalate nephropathy is a rare cause of renal failure. Primary Hyperoxaluria (PH) is due to glyoxylate metabolism disorders with specific hepatic enzyme deficiencies. Secondary hyperoxaluria is caused by increased intestinal absorption, excessive dietary intake or excessive intake of oxalate precursors. This study reports on a 4-month-old male with high serum creatinine level, low serum sodium and calcium, high uric acid, and low urine specific gravity. Sonography showed calcification of medullary papilla (nephrocalcinosis). In kidney biopsy, many polarizing intra-tubular and interstitial calcium oxalate crystals, mild patchy lymphocytic infiltration, and interstitial fibrosis were noted. Despite supportive therapies and correction of fluid and electrolyte abnormalities, the patient gradually became oliguric progressing to anuria, and was placed on peritoneal dialysis.

【 授权许可】

Unknown