Effect of Vitamin D Supplementation and Calcium in Reducing the Risk of Preeclampsia: Meta-Analysis

Indonesian Journal of Medicine

ARTICLE

Fanny Kartika Fajriyani¹  Eti Poncorini Pamungkasari¹  Bhisma Murti¹ 

[1] Masters Program in Public Health, Universitas Sebelas Maret Faculty of Medicine, Universitas Sebelas Maret

关键词: vitamin D;    Calcium;    preeclampsia;    randomized controlled trial;   

DOI  :  10.26911/theijmed.2020.05.04.06.

学科分类：眼科学

来源: Masters Program in Public Health, Universitas Sebelas Maret

【 摘 要 】

Background: Preeclampsia (PE) is a major complication in pregnancy and a major cause of maternal and fetal morbidity and mortality. Analysis of risk factors and prevention of pre­eclampsia are needed to reduce the adverse effects of preeclampsia. Important supplements during pregnancy to prevent the increase in blood pressure of pregnant women are Vitamin D and calcium. This study aimed to analyze the effect of vitamin D and calcium supplemen­tation on reducing the risk of preeclampsia. Subjects and Method: This study is a meta-analysis of a number of randomized controlled trials. The articles used in this study were obtained from several databases including PubMed, Google Scholar, Springerlink, and Sciencedirect. The articles used in this study were those published from 2002-2020. The article search was carried out by considering the eligibility criteria defined using the PICO model. P: Pregnant women, I: vitamin D and calcium, C: placebo, and O: preeclampsia. The keywords to find articles are as follows: "Vitamin D" OR "Calcium" OR "Vitamin D and Calcium" AND "preeclampsia" AND "Rando­mized Controll Trials". The articles included in this study are full text articles with Cross-sectional study design. Articles were collected using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3. Results: A total of 9 articles were reviewed in this study. The meta-analysis showed that vitamin D supplementation reduced the risk of preeclampsia in pregnant women (RR= 0.45, 95% CI 0.32-0.63, p<0.001). The meta-ana­lysis of 8 articles also showed that calcium supple­mentation reduced the risk of preeclampsia in pregnant women with calcium (RR= 0.42; 95% CI= 0.31 - 0.57; p<0.001). This meta-analysis combines primary research from Iran, India, Bangladesh, South Africa, Cameroon, and Saudi Arabia. Conclusion: Vitamin D and calcium supple­mentation reduces the risk of preeclampsia.

【 授权许可】

CC BY-NC-SA