Association of p53 Expression with Metabolic Features of Stage I Non-Small Cell Lung Cancer.

Tuberculosis and Respiratory Diseases

article

Kang, Shin Myung¹  Koh, Won Jung¹  Suh, Gee Young¹  Chung, Man Pyo¹  Han, Joungho³  Kim, Hojoong¹  Kwon, O Jung¹  Um, Sang Won¹ 

[1] Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine;Department of Pulmonary and Critical Care Medicine, Gachon University Gil Hospital, Incheon;Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine

关键词: Tumor Suppressor Protein p53;    Necrosis;    Positron-Emission Tomography;    Carcinoma;    Non-Small-Cell Lung;   

DOI  :  10.4046/trd.2011.71.6.417

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

BACKGROUND Recent evidences have revealed metabolic functions of p53 in cancer cells; adaptation or survival to metabolic stress and metabolic shift toward oxidative phosphorylation. However, further studies in clinical setting are needed. We investigated whether p53 protein expression, as a surrogate marker for loss of p53 function, is associated with metabolic features of stage I non-small cell lung cancer (NSCLC), focusing on tumor necrosis and maximal standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography. METHODS: Clinical information was obtained from retrospective review of medical records. p53 expression was assessed by immunohistochemical staining. RESULTS: p53 protein expression was detected in 112 (46%) of 241 NSCLC cases included in this study. p53 expression was independently associated with the presence of necrosis (odds ratio [OR], 2.316; 95% confidence interval [CI], 1.215~4.416; p=0.011). Non-adenocarcinoma histology (OR, 8.049; 95% CI, 4.072~15.911; p<0.001) and poorly differentiation (OR, 6.474; 95% CI, 2.998~13.979; p<0.001) were also independently associated with the presence of necrosis. However, p53 expression was not a significant factor for SUVmax. CONCLUSION: p53 protein expression is independently associated with the presence of necrosis, but not SUVmax.

【 授权许可】

CC BY-NC