Prognostic Value of Preoperative Positron Emission Tomography-Computed Tomography in Surgically Resected Stage I and II Non-Small Cell Lung Cancer.

Tuberculosis and Respiratory Diseases

article

Song, Sung Heon¹  Sohn, Jang Won²  Kwak, Hyun Jung²  Kim, Sa Il²  Kim, Sang Heon²  Kim, Tae Hyung²  Yoon, Ho Joo²  Shin, Dong Ho²  Choi, Yoon Young³  Park, Sung Soo² 

[1] Division of Pulmonology, Cheju Halla General Hospital;Departments of Internal Medicine, Hanyang University College of Medicine;Departments of Nuclear Medicine, Hanyang University College of Medicine

关键词: Carcinoma;    Non-Small Cell Lung;    Positron-Emission Tomography;    Prognosis;   

DOI  :  10.4046/trd.2011.71.6.425

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

BACKGROUND High 2-[18F] fluoro-2-deoxy-D-glucose (FDG) uptake on positron emission tomography-computed tomography (PET-CT) is a prognostic factor for poor survival in non-small cell lung cancer (NSCLC), especially in Stage I. We determined whether the high FDG uptake value of a primary tumor was associated with recurrence and death in patients with resected Stage I and Stage II NSCLC. METHODS: We identified consecutive patients who underwent complete surgical resection for Stage I and II NSCLC between 2006 and 2009, who had preoperative PET-CT, and reviewed clinical records retrospectively. FDG uptake was measured as the maximal standardized uptake value (SUVmax) for body weight. Patients were divided into two groups based on SUVmax: (i) above or (ii) below the cut-off value (SUVmax=5.9) determined by a receiver operating characteristic (ROC) curve. RESULTS: Of 57 patients who were enrolled consecutively, 32 (56%) had Stage I NSCLC and 25 (44%) had Stage II. The 5-year recurrence-free survival (RFS) for patients with high (> or =5.9) and low (<5.9) SUVmax were 31% and 57%, respectively (p=0.014). The 5-year overall survival (OS) rates were 39% and 60%, respectively (p=0.029). In univariate analyses, SUVmax (p=0.014), T staging (p=0.025), and differentiation of tumor tissue (p=0.034) were significantly associated with RFS. But, multivariate analyses did not show that SUVmax was an independently significant factor for RFS (p=0.180). CONCLUSION: High FDG uptake on PET-CT is not an independent prognostic factor for poor outcomes (disease recurrence in patients with resected Stage I and II NSCLC).

【 授权许可】

CC BY-NC