A Case of Prothionamide Induced Hepatitis on Patient with Multi-Drug Resistant Pulmonary Tuberculosis.

Tuberculosis and Respiratory Diseases

article

Park, Jun Beom¹  Park, Byung Hoon¹  Son, Ji Young¹  Jung, Ji Ye¹  Kim, Eun Young¹  Lim, Ju Eun¹  Lee, Sang Hoon¹  Lee, Sang Kook¹  Kim, Song Yee¹  Jung, Wonjai¹  Lim, Seungtaek¹  Lee, Kyung Jong¹  Kang, Young Ae¹  Kim, Young Sam¹  Kim, Se Kyu¹  Chang, Joon¹  Choi, Junjeong³  Park, Moo Suk¹ 

[1] Departments of Internal Medicine, Yonsei University College of Medicine;The Institute of Chest Diseases, Yonsei University College of Medicine;Departments of Pathology, Yonsei University College of Medicine

关键词: Tuberculosis;    Multidrug-Resistant;    Hepatitis;    Prothionamide;   

DOI  :  10.4046/trd.2011.70.3.251

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

The prevalence of multi-drug resistant tuberculosis (MDR-TB), which is resistant to isoniazid and rifampin, has been increasing in Korea. And the side effects of 2nd line anti-tuberculosis medications, including drug-induced hepatitis, are well known. Although prothionamide (PTH) is one of the most useful anti-TB medications and although TB medication-induced acute hepatitis is a severe complication, there are only a few published case reports about prothionamide induced hepatitis. In this case report, a 22 year old male was diagnosed with pulmonary MDR-TB and was administered 2nd line anti-TB mediations, including PTH. Afterwards, he had a spiking fever and his liver enzymes were more than 5 times greater than the upper limit of the normal range. He was then diagnosed with drug-induced hepatitis by liver biopsy. His symptoms and liver enzyme elevation were improved after stopping PTH. Accordingly, we report this case of an association between PTH and acute hepatitis.

【 授权许可】

CC BY-NC