Proteomics for Cerebrospinal Fluid Biomarker Identification in Parkinson’s Disease: Methods and Critical Aspects

AIMS Medical Science

article

Antonio Conti¹  Massimo Alessio¹ 

[1] Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute

关键词: cerebrospinal fluid;    Parkinson's disease;    biomarker;    quantitative proteomics;    post translational modifications;    mass spectrometry;    two-dimensional electrophoresis;    ;   

DOI  :  10.3934/medsci.2015.1.1

来源: American Institute of Mathematical Sciences

【 摘 要 】

Parkinson’s disease (PD), similar with other neurodegenerative disorders, would benefit from the identification of early biomarkers for differential diagnosis and prognosis to address prompt clinical treatments. Together with hypothesis driven approaches, PD has been investigated by high-throughput differential proteomic analysis of cerebrospinal fluid (CSF) protein content. The principal methodologies and techniques utilized in the proteomics field for PD biomarker discovery from CSF are presented in this mini review. The positive aspects and challenges in proteome-based biomarker research are also discussed.

【 授权许可】

CC BY