Suitability of the woodchuck HCC as a preclinical model for evaluation of intra-arterial therapies

Animal Models and Experimental Medicine

article

Alexander Y. Kim¹  Joseph H. Yacoub¹  David H. Field¹  Byoung Uk Park²  Bhaskar Kallakury²  Kyle E. Korolowicz³  Stephan Menne³ 

[1] Department of Radiology, Medstar Georgetown University Hospital;Department of Pathology and Laboratory Medicine, Medstar Georgetown University Hospital;Department of Microbiology and Immunology, Georgetown University Medical Center

关键词: angiography;    animal model;    hepatocellular carcinoma;    woodchuck;   

DOI  :  10.1002/ame2.12100

学科分类：机械工程学

来源: Wiley

【 摘 要 】

The most commonly used preclinical models of hepatocellular carcinoma (HCC) are limited for use in testing of intra-arterial therapies such as transarterial chemoembolization and radioembolization. Issues encountered with the more commonly used animal models include dissimilarity in their disease development compared with humans and the size of the vasculature which can make intra-arterial therapy testing difficult or impossible. Here we describe the suitability of the woodchuck HCC model for testing of intra-arterial therapies. We describe the techniques for pre-embolization imaging assessment using CT and MRI, technical tips on performing angiography and embolization, and pathological assessment of treated liver.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND