Oral Leiomyosarcoma in a Woodchuck (Marmota monax)

Journal of Veterinary Medical Science

Dong-Deuk JANG³  Sang-Koo LEE²  Byeong-Cheol KANG¹ 

[1] Xenotransplantation Research Center;Center for Laboratory Animal Sciences, College of Medicine, Hanyang University;Department of Pathology, National Institute of Toxicological Research

关键词: leiomyosarcoma;    oral neoplasm;    woodchuck;   

DOI  :  10.1292/jvms.67.353

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(12)Cited-By(2)We report the case of a 4-year-old female woodchuck (Marmota monax) which presented with a white, firm and discrete mass in the hard palate. The mass extended into the oral cavity but it was well separated from the surrounding tissues. Histology of the tumor showed a malignant mesenchymal tumor with pleomorphic spindle cells varying in degrees of differentiation and density. The neoplastic cells had moderate amounts of granular or fibrillar eosinophilic cytoplasm with indistinct cell margins. Nuclei were oval to elongated and frequently blunt-ended with vesicular chromatin. Immunohistochemical study showed that the neoplastic cells expressed vimentin and alpha-smooth muscle actin but did not express desmin, pan-cytokeratin, and S-100. Therefore, histology and immunohistochemistry revealed that the tumor was oral leiomyosarcoma. Oral cavity is an extremely rare site for leiomyosarcoma and the present case is the first report of spontaneous oral leiomyosarcoma in animals.

【 授权许可】

Unknown