Animal Models and Experimental Medicine | |
The promises and challenges of patient-derived tumor organoids in drug development and precision oncology | |
article | |
Lauren M. Granat1  Ooha Kambhampati1  Stephanie Klosek1  Brian Niedzwecki1  Kian Parsa1  Dong Zhang1  | |
[1] Department of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology | |
关键词: drug testing; patient derived tumor organoids; precision oncology; tumor models; | |
DOI : 10.1002/ame2.12077 | |
学科分类:机械工程学 | |
来源: Wiley | |
【 摘 要 】
In the era of precision medicine, cancer researchers and oncologists are eagerly searching for more realistic, cost effective, and timely tumor models to aid drug de‐ velopment and precision oncology. Tumor models that can faithfully recapitulate the histological and molecular characteristics of various human tumors will be extremely valuable in increasing the successful rate of oncology drug development and discov‐ ering the most efficacious treatment regimen for cancer patients. Two‐dimensional (2D) cultured cancer cell lines, genetically engineered mouse tumor (GEMT) models, and patient‐derived tumor xenograft (PDTX) models have been widely used to inves‐ tigate the biology of various types of cancers and test the efficacy of oncology drug candidates. However, due to either the failure to faithfully recapitulate the complex‐ ity of patient tumors in the case of 2D cultured cancer cells, or high cost and untimely for drug screening and testing in the case of GEMT and PDTX, new tumor models are urgently needed. The recently developed patient‐derived tumor organoids (PDTO) offer great potentials in uncovering novel biology of cancer development, accelerat‐ ing the discovery of oncology drugs, and individualizing the treatment of cancers. In this review, we will summarize the recent progress in utilizing PDTO for oncology drug discovery. In addition, we will discuss the potentials and limitations of the cur‐ rent PDTO tumor models.
【 授权许可】
CC BY|CC BY-NC|CC BY-NC-ND
【 预 览 】
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RO202105310001434ZK.pdf | 1577KB | download |