Facial nerve repair utilizing intraoperative repair strategies

Laryngoscope Investigative Otolaryngology

article

Brandon L. Brown¹  Morgan M. Sandelski¹  Sarah M. Drejet³  Elizabeth M. Runge¹  Taha Z. Shipchandler³  Kathryn J. Jones¹  Chandler L. Walker¹ 

[1] Department of Anatomy, Indiana University School of Medicine;Department of Anatomical Sciences and Neurobiology, University of Louisville;Department of Otolaryngology, Indiana University School of Medicine;Research and Development Service, Richard L Roudebush Veterans Affairs Medical Center;Department of Biomedical Sciences and Comprehensive Care, Indiana University School of Dentistry

关键词: electrical stimulation;    facial nerve;    facial nerve injury;    nerve repair;    polyethylene glycol;   

DOI  :  10.1002/lio2.411

学科分类：环境科学（综合）

来源: Wiley

【 摘 要 】

Objectives: To determine whether functional and anatomical outcomes following suture neurorrhaphy are improved by the addition of electrical stimulation with or without the addition of polyethylene glycol (PEG). Methods: In a rat model of facial nerve injury, complete facial nerve transection and repair was performed via (a) suture neurorrhaphy alone, (b) neurorrhaphy with the addition of brief (30 minutes) intraoperative electrical stimulation, or (c) neurorrhaphy with the addition electrical stimulation and PEG. Functional recovery was assessed weekly for 16 weeks. At 16 weeks postoperatively, motoneuron survival, amount of regrowth, and specificity of regrowth were assessed by branch labeling and tissue analysis. Results: The addition of brief intraoperative electrical stimulation improved all functional outcomes compared to suturing alone. The addition of PEG to electrical stimulation impaired this benefit. Motoneuron survival, amount of regrowth, and specificity of regrowth were unaltered at 16 weeks postoperative in all treatment groups. Conclusion: The addition of brief intraoperative electrical stimulation to neurorrhaphy in this rodent model shows promising neurological benefit in the surgical repair of facial nerve injury.

【 授权许可】

CC BY|CC BY-NC-ND