Multiple functions of DYRK2 in cancer and tissue development

FEBS Letters

article

Saishu Yoshida¹  Kiyotsugu Yoshida¹ 

[1] Department of Biochemistry, The Jikei University School of Medicine

关键词: apoptosis;    cancer;    development;    dyrk2;    EMT;    kinase;    phosphorylation;    stemness;   

DOI  :  10.1002/1873-3468.13601

来源: John Wiley & Sons Ltd.

【 摘 要 】

Dual-specificity tyrosine-regulated kinases (DYRKs) are evolutionarily conserved from yeast to mammals. Accumulating studies have revealed that DYRKs have important roles in regulation of the cell cycle and survival. DYRK2, a member of the class II DYRK family protein, is a key regulator of p53, and phosphorylates it at Ser46 to induce apoptosis in response to DNA damage. Moreover, recent studies have uncovered that DYRK2 regulates G1/S transition, epithelial-mesenchymal-transition, and stemness in human cancer cells. DYRK2 also appears to have roles in tissue development in lower eukaryotes. Thus, the elucidation of mechanisms for DYRK2 during mammalian tissue development will promote the understanding of cell differentiation, tissue homeostasis, and congenital diseases as well as cancer. In this review, we discuss the roles of DYRK2 in tumor cells. Moreover, we focus on DYRK2-dependent developmental mechanisms in several species including fly (Drosophila), worm (Caenorhabditis elegans), zebrafish (Danio rerio), and mammals.

【 授权许可】

Unknown