UCP2 gene polymorphisms in obesity and diabetes, and the role of UCP2 in cancer

FEBS Letters

article

Jinran Li¹  Rihua Jiang¹  Xianling Cong¹  Yunfeng Zhao² 

[1] Department of Dermatology, China-Japan Union Hospital, Jilin University;Department of Pharmacology, LSU Health Sciences Center

关键词: cancer;    diabetes;    mitochondria;    obesity;    polymorphism;    UCP2;   

DOI  :  10.1002/1873-3468.13546

来源: John Wiley & Sons Ltd.

【 摘 要 】

Mitochondria are the primary sites for ATP synthesis and free radical generation in organisms. Abnormal mitochondrial metabolism contributes to many diseases, including obesity, diabetes and cancer. UCP2 is an ion/anion transporter located in mitochondrial inner membrane, and has a crucial role in regulating oxidative stress, cellular metabolism, cell proliferation and cell death. Polymorphisms of the UCP2 gene have been associated with diabetes and obesity because UCP2 is involved in energy expenditure and insulin secretion. Moreover, UCP2 gene expression is often amplified in cancers, and increased UCP2 expression contributes to cancer growth, cancer metabolism, antiapoptosis and drug resistance. The present review summarizes the latest findings of UCP2 with respect to obesity, diabetes and cancer.

【 授权许可】

Unknown