Evaluation of the safety and efficacy of beta blockers in septic patients: a randomized control trial

Ain-Shams Journal of Anesthesiology

Raouf Ramzy Gadallah¹  Eman Mohamed Kamal Aboseif¹  Mohamed Nabil Mohamed Abdelmaksoud¹  Hany Victor Zaki¹  Dalia Ahmed Ibrahim¹ 

[1] Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain-Shams University, Abbassia, 11591, Cairo, Egypt;

关键词: Sepsis;    Beta Blocker;    Mortality;    ICU;   

DOI  :  10.1186/s42077-020-00107-5

来源: Springer

【 摘 要 】

BackgroundSepsis is a common fatal complication of an infection. As part of the host response, sympathetic stimulation can result in many serious complications such as septic myocardial depression and metabolic, hematological, and immunological dysfunction. Treatment with beta blockers may reduce this pathophysiological response to infection, but the clinical outcomes are not clear.ResultsOur study showed a significant difference as regards decrease in heart rate in group B with P value < 0.001 compared to group A, besides a reduction in 28-day mortality (P value 0.0385) and ICU stay (P value < 0.001) in group B compared to group A.ConclusionThis study supports the role of intravenous beta blockers in sepsis patients by decreasing heart rate without affecting the hemodynamics, in addition to decreasing 28-day mortality and ICU stay.

【 授权许可】

CC BY