The obesity conundrum in sepsis

BMC Anesthesiology

Editorial

Pauline Yeung Ng¹  Matthias Eikermann² 

[1] Adult Intensive Care Unit, Queen Mary Hospital and The University of Hong Kong, Pok Fu Lam, Hong Kong;Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA;

关键词: Obesity;    Overweight;    Sepsis;    Septic shock;    Obesity paradox;    Mortality;    ICU;    Meta-analysis;   

DOI  :  10.1186/s12871-017-0434-z

 received in 2017-09-12, accepted in 2017-10-09,  发布年份 2017

来源: Springer

【 摘 要 】

While the long-term negative effects of obesity on health is a well-studied phenomenon, its effects on acute illnesses seem to be the contrary. Several studies have indicated the possibility of an ‘obesity paradox’ in sepsis – where overweight and obese patients have better outcomes than normal weight patients. These meta-analyses including large numbers of patients across different countries raised an interesting but debatable topic. Results from meta-analyses of observational studies should be interpreted with caution, and a prove of association not be mistaken as prove of causality. Limitations common to such studies include inadequate adjustment for confounding and selection bias. More rigorous investigations to clarify any causal relationship between obesity and mortality in sepsis are needed.

【 授权许可】

CC BY   
© The Author(s). 2017