Glucose metabolism-related gene polymorphisms as the risk predictors of type 2 diabetes

Diabetology & Metabolic Syndrome

Hong Liu¹  Qiuhong Tan²  Yuping Yang²  Xin Liu²  Cuilin Li²  Zhongyu Li³ 

[1] Department of Metabolism and Endocrinology, The Affiliated Zhuzhou Hospital Xiangya Medical College CSU, 412007, Zhuzhou, China;Department of Pharmacy, The Affiliated Zhuzhou Hospital Xiangya Medical College CSU, 412007, Zhuzhou, Hunan, China;Laboratory Medical Center, The Affiliated Zhuzhou Hospital Xiangya Medical College CSU, 412007, Zhuzhou, China;

关键词: Type 2 diabetes mellitus;    Genetic polymorphism;    G6PC2;    GCK;    GCKR;    OCT3;   

DOI  :  10.1186/s13098-020-00604-5

来源: Springer

【 摘 要 】

Type 2 diabetes mellitus (T2DM) is a complex polygenic metabolic disease characterized by elevated blood glucose. Multiple environmental and genetic factors can increase the risk of T2DM and its complications, and genetic polymorphisms are no exception. This review is mainly focused on the related genes involved in glucose metabolic, including G6PC2, GCK, GCKR and OCT3. In this review, we have summarized the results reported globally and found that the genetic variants of GCK and OCT3 genes is a risk factor for T2DM while G6PC2 and GCKR genes are controversial in different ethnic groups. Hopefully, this summary could possibly help researchers and physicians understand the mechanism of T2DM so as to diagnose and even prevent T2DM at early time.

【 授权许可】

CC BY