Inter-organelle membrane contact sites: implications for lipid metabolism

Biology Direct

Jean E. Vance¹ 

[1] Department of Medicine and Group on Molecular and Cell Biology of Lipids, University of Alberta, T6G 2S2, Edmonton, AB, Canada;

关键词: Membrane contact sites;    Phospholipid transport;    Cholesterol transport;    Mitochondria;    Mitochondria-associated membranes (MAM);    Endoplasmic reticulum;    Plasma membrane;   

DOI  :  10.1186/s13062-020-00279-y

来源: Springer

【 摘 要 】

This article supplements a recent Perspective by Scorrano et al. in Nature Communications [10 [ (1)]:1287] in which the properties and functions of inter-organelle membrane contact sites were summarized. It is now clear that inter-organelle membrane contact sites are widespread in eukaryotic cells and that diverse pairs of organelles can be linked via unique protein tethers. An appropriate definition of what constitutes an inter-organelle membrane contact site was proposed in the Perspective. In addition, the various experimental approaches that are frequently used to study these organelle associations, as well as the advantages and disadvantages of each of these methods, were considered. The nature of the tethers that link the pairs of organelles at the contact sites was discussed in detail and some biological functions that have been ascribed to specific membrane contact sites were highlighted. Nevertheless, the functions of most types of organelle contact sites remain unclear. In the current article I have considered some of the points raised in the Perspective but have omitted detailed information on the roles of membrane contact sites in biological functions such as apoptosis, autophagy, calcium homeostasis and mitochondrial fusion. Instead, I have provided some background on the initial discovery of mitochondria-endoplasmic reticulum membrane contact sites, and have focussed on the known roles of membrane contact sites in inter-organelle lipid transport. In addition, potential roles for membrane contact sites in human diseases are briefly discussed.

【 授权许可】

CC BY