SFF analysis of the small angle scattering data for investigation of a vesicle systems structure

21st International School on Nuclear Physics and Applications & International Symposium on Exotic Nuclei

Zemlyanaya, E.V.^1 ; Kiselev, M.A.^1 ; Zhabitskaya, E.I.^1 ; Gruzinov, A.Yu.^2 ; Aksenov, V.L.^1,3 ; Ipatova, O.M.^4 ; Druzhilovskaya, O.S.^4

Joint Institute for Nuclear Research, Dubna

141980, Russia^1

National Research Center Kurchatov Institute, Moscow, Russia^2

Peterburg Institute of Nuclear Physics, NRC Kurchatov Institute, Gatchina, Russia^3

V.N. Orekhovich Research Institute for Biomedical Chemistry, Moscow, Russia^4

关键词: Basic parameters;    Form factors;    Phospholipid transport;    Small angle scattering;    Synchrotron X-ray scattering;    Systems Structure;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/724/1/012056/pdf
DOI  :  10.1088/1742-6596/724/1/012056

来源: IOP

【 摘 要 】

Experimental data on the small angle synchrotron X-ray scattering (SAXS) are analyzed on a basis of Separated form factors method (SFF) for a study of the drug delivery Phospholipid Transport Nano System (PTNS). Basic parameters of polydispersed population of PTNS nanoparticles (average radius of PTNS-particles, polydispersity of radius, thickness of membrane) have been determined. The results are discussed in comparison with the SFF results for the "classical" vesicular system of dimyristoylphosphocholine (DMPC).