Quality of life and mortality in the general population: a systematic review and meta-analysis

BMC Public Health

Nigel P. Stocks¹  David A. Gonzalez-Chica²  Aung Zaw Zaw Phyo³  Heather Craig³  Rosanne Freak-Poli⁴  Joanne Ryan⁵  Danijela Gasevic⁶ 

[1] Discipline of General Practice, Adelaide Medical School, The University of Adelaide, 5005, Adelaide, SA, Australia;Discipline of General Practice, Adelaide Medical School, The University of Adelaide, 5005, Adelaide, SA, Australia;Adelaide Rural Clinical School, The University of Adelaide, 5005, Adelaide, SA, Australia;School of Public Health and Preventive Medicine, Monash University, 99 Commercial Road, 3004, Melbourne, VIC, Australia;School of Public Health and Preventive Medicine, Monash University, 99 Commercial Road, 3004, Melbourne, VIC, Australia;Department of Epidemiology, Erasmus Medical Centre, 3015 GD, Rotterdam, The Netherlands;School of Public Health and Preventive Medicine, Monash University, 99 Commercial Road, 3004, Melbourne, VIC, Australia;PSNREC, Univ Montpellier, INSERM, 34000, Montpellier, France;School of Public Health and Preventive Medicine, Monash University, 99 Commercial Road, 3004, Melbourne, VIC, Australia;Usher Institute, University of Edinburgh, Teviot Place, EH8 9AG, Edinburgh, UK;

关键词: Quality of life;    Life quality;    Health-related quality of life;    Mortality;    Meta-analysis;    Predictor;    Review;   

DOI  :  10.1186/s12889-020-09639-9

来源: Springer

【 摘 要 】

BackgroundQuality of life (QoL) is multi-dimensional concept of an individual’ general well-being status in relation to their value, environment, cultural and social context in which they live. This study aimed to quantitatively synthesise available evidence on the association between QoL and mortality in the general population.MethodsAn electronic search was conducted using three bibliographic databases, MEDLINE, EMBASE and PsycINFO. Inclusion criteria were studies that assessed QoL using standardized tools and examined mortality risk in a non-patient population. Qualitative data synthesis and meta-analyses using a random-effects model were performed.ResultsOf 4184 articles identified, 47 were eligible for inclusion, involving approximately 1,200,000 participants. Studies were highly heterogeneous in terms of QoL measures, population characteristics and data analysis. In total, 43 studies (91.5%) reported that better QoL was associated with lower mortality risk. The results of four meta-analyses indicated that higher health-related QoL (HRQoL) is associated with lower mortality risk, which was consistent for overall HRQoL (HR 0.633, 95% CI: 0.514 to 0.780), physical function (HR 0.987, 95% CI: 0.982 to 0.992), physical component score (OR 0.950, 95% CI: 0.935 to 0.965), and mental component score (OR 0.980, 95% CI: 0.969 to 0.992).ConclusionThese findings provide evidence that better QoL/HRQoL was associated with lower mortality risk. The utility of these measures in predicting mortality risk indicates that they should be considered further as potential screening tools in general clinical practice, beyond the traditional objective measures such as body mass index and the results of laboratory tests.

【 授权许可】

CC BY