Protective effects of peel extracts of Irvingia wombolu on metabolic disorders in streptozotocin-induced diabetic rats

Clinical Phytoscience

Valere Aime Soh Oumbe¹  Julius Enyong Oben²  Judith Laure Ngondi²  Rosane Soh Matsinkou³ 

[1]Department of Biochemistry, University of Douala, Laboratory of Biochemistry, PO. Box: 24157, Douala, Cameroon

[2]Department of Biochemistry, University of Yaounde I, Laboratory of Nutrition and Nutritional Biochemistry, PO. Box: 812, Yaounde, Cameroon

[3]Department of Food Sciences and Nutrition, University of Ngaoundere, Laboratory of Biophysic Food Biochemistry and Metabolism, ENSAI, PO. Box: 455, Ngaoundere, Cameroon

[4]Department of Biochemistry, University of Yaounde I, Laboratory of Nutrition and Nutritional Biochemistry, PO. Box: 812, Yaounde, Cameroon

关键词: Diabetes;    Irvingia wombolu;    Peel extracts;    Protective effects;    Rats;    Streptozotocin;   

DOI  :  10.1186/s40816-020-00218-4

来源: Springer

【 摘 要 】

BackgroundDiabetes is widely recognized as associated with several structural and functional liver, kidney, and heart abnormalities. Therefore, the present study was conducted to evaluate the protective effect of peel extracts of Irvingia wombolu against diabetes complications.MethodsDiabetes was induced by intravenous administration of streptozotocin (STZ) (50 mg/kg) through the right jugular vein on rats and animals with blood glucose values of at least 250 mg/dl received orally aqueous extract of peel (AEP), hydroethanolic extract of peel (HEP), tolbutamide and DMSO 10%. Their effects on the concentration of blood glucose, total cholesterol, HDL-C, LDL-C, triglycerides, malondialdehyde (MDA) and activities of catalase (CAT), reduced glutathione (GSH), superoxide dismutase (SOD), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in diabetic and normal rats were investigated using standard methods.ResultsTwenty-one days of treatment with AEP and HEP at a dose of 400 mg/kg significantly (P < 0,05) reduced the fasting blood glucose to a point of reaching normal value. The antihyperlipidemic assessment of extracts revealed a significant (P < 0,05) decrease in total cholesterol, triglycerides, LDL levels, and a significant (P < 0,05) increase in HDL level in the plasma of treated diabetic rats. Furthermore, plasma biomarkers of liver and kidney dysfunction were significantly reduced in treated diabetic rats. We also observed increased activities of catalase, SOD, and reduced glutathione in diabetic treated rats.ConclusionThe present findings suggest that AEP and HEP have a protective effect on liver, kidney, and heart in experimental diabetic rats which can be beneficial in the management of diabetes and its complications.

【 授权许可】

CC BY