Investigating the effects and possible mechanisms of danshen- honghua herb pair on acute myocardial ischemia induced by isoproterenol in rats

Biomedicine & Pharmacotherapy

Li-Na Quan¹  Ji-Qing Bai¹  Peng-Fei Wang²  Yun-Dong Xie³  Ya-Heng Wang³  Su Gao³  Xiao-Ping Wang³  Jin Wang³  Fang Wang³  Xiao-Ting Wang³ 

[1]Corresponding authors at: Shaanxi University of Chinese Medicine • Shiji Ave., Xi'an-Xianyang New Ecomic Zone, Shaanxi Province, PR China.

[2]Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, Shaanxi University of Chinese Medicine, Xianyang 712046, China

[3]College of pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China

关键词: Salvia miltiorrhiza;    Carthamustinctorius;    Herb pair;    Acute myocardial ischemia;    Protective effects;    Potential;   

DOI  :  

来源: DOAJ

【 摘 要 】

Danshen (salvia miltiorrhiza) and honghua(Carthamus tinctorius) were traditional herb pair with promoting blood circulation and removing blood stasis actions, in China. Both were widely used to treat cardiovascular diseases (CVD) for hundreds years, especially shown definite advantage in the treatment of ischemic heart disease (IHD). However, the mechanism of danshen-honghua herb pair (DHHP) in the treatment of IHD was still unclear. This study was focused on examining the effects and possible mechanisms of DHHP in rats with acute myocardial ischemia induced by isoproterenol (ISO). The results suggested that DHHP significantly ameliorated the myocardial tissue abnormalities, notablely inhibited the elevation of lactate dehydrogenase (LDH), creatine kinase (CK), aspartate aminotransferase (AST), creatinekinase isoenzyme (CK-MB) and cardiac troponin T (CTn-T) in plasma, obviously decreased the plasma levels of Tumor Necrosis Factor α (TNF-α), outstandingly inhibited the reduction of superoxide dismutase (SOD), catalase (CAT) caused by ISO, significantly inhibited the high expression of Bcl-2 assaciated X protein (Bax) and nuclear transcriptionfactor-κBP65 (NF-κBP65) protein, significantly induced the low expression of B-cell lymphoma-2 (Bcl–2) protein in acute myocardial ischemia rats. DHHP can obviously ameliorate hemodynamic parameters. In summary, DHHP can significantly improve myocardial ischemia in acute myocardial ischemia model rats caused by ISO. Anti-free radicals, anti-peroxidation, inhibition of cell apoptosis and anti– inflammation maybe are the potential mechanisms of DHHP anti-myocardial ischemia in acute myocardial ischemia rats in duced by ISO.

【 授权许可】

Unknown