EJNMMI Research | |
Striatal dopamine transporter SPECT quantification: head-to-head comparison between two three-dimensional automatic tools | |
Maria Isabella Donegani1  Alberto Miceli1  Stefano Raffa1  Silvia Morbelli2  Federico Massa3  Eugenia Cella3  Laura Filippi3  Andrea Chincarini4  Selene Capitanio5  Flavio Nobili6  Dario Arnaldi6  | |
[1] Department of Health Science (DISSAL), University of Genoa, Genoa, Italy;Department of Health Science (DISSAL), University of Genoa, Genoa, Italy;IRCCS Ospedale Policlinico San Martino, Genoa, Italy;Department of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy;Genoa Section, National Institute of Nuclear Physics (INFN), Genoa, Italy;IRCCS Ospedale Policlinico San Martino, Genoa, Italy;IRCCS Ospedale Policlinico San Martino, Genoa, Italy;Department of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy; | |
关键词: Dopamine transporter; SPECT; Parkinson; Datquant®; BasGanV2; Semi-quantification; | |
DOI : 10.1186/s13550-020-00727-w | |
来源: Springer | |
【 摘 要 】
PurposeOur aim was to compare a widely distributed commercial tool with an older free software (i) one another, (ii) with a clinical motor score, (iii) versus reading by experts.ProceduresWe analyzed consecutive scans from one-hundred and fifty-one outpatients submitted to brain DAT SPECT for a suspected parkinsonism. Images were post-processed using a commercial (Datquant®) and a free (BasGanV2) software. Reading by expert was the gold standard. A subset of patients with pathological or borderline scan was evaluated with the clinical Unified Parkinson’s Disease Rating Scale, motor part (MDS-UPDRS-III).ResultsSBR, putamen-to-caudate (P/C) ratio, and both P and C asymmetries were highly correlated between the two software with Pearson’s ‘r’ correlation coefficients ranging from .706 to .887. Correlation coefficients with the MDS-UPDRS III score were higher with caudate than with putamen SBR values with both software, and in general higher with BasGanV2 than with Datquant®. Datquant® correspondence with expert reading was 84.1% (94.0% by additionally considering the P/C ratio as a further index). BasGanV2 correspondence with expert reading was 80.8% (86.1% by additionally considering the P/C ratio).ConclusionsBoth Datquant® and BasGanV2 work reasonably well and similarly one another in semi-quantification of DAT SPECT. Both tools have their own strength and pitfalls that must be known in detail by users in order to obtain the best help in visual reading and reporting of DAT SPECT.
【 授权许可】
CC BY
【 预 览 】
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