Oxidative stress and its association with ST resolution and clinical outcome measures in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention

BMC Research Notes

Samad Ghaffari¹  Elmira Matin¹  Naser Safaie¹  Neda Roshanravan¹  Naimeh Mesri Alamdari²  Somaieh Matin³  Alireza Garjani⁴ 

[1] Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran;Department of Internal Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran;Department of Pharmacology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran;

关键词: Ischemia reperfusion injury;    Oxidative stress;    Myocardial infarction;   

DOI  :  10.1186/s13104-020-05350-5

来源: Springer

【 摘 要 】

ObjectiveReperfusion of ischemic myocardium generates oxidative stress, which itself can mediate myocardial injury. So, in this study, we investigated the level of oxidative stress markers and its association with clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention.ResultsAs indicated in the results, Post MI (Myocardial Infarction) heart failure was significantly higher in the group A (11% vs 4%, p = 0.047). Complete STR (ST-segment resolution) was observed to be significantly higher in the group B (36% vs 17%, p = 0.006). The SOD (Superoxide dismutase) and GPX (Glutathione peroxidase) levels were significantly higher in the group B compared to the other group (1547.51 ± 328.29 vs. 1449.97 ± 246.06, p = 0.019 and 60.62 ± 11.95 vs 57.41 ± 10.14, p = 0.042). The levels of GPX and SOD were shown to be directly related with complete STR and post PCI (Percutaneous coronary intervention)TIMI(Thrombolysis in Myocardial Infarction) flow 3 in the group A (p = 0.002 and p < 0.01, p = 0.005 and p < 0.02, respectively).

【 授权许可】

CC BY