Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus

Molecular Brain

Yasmine Belaidouni¹  Jean-Luc Gaiarsa¹  Diabe Diabira¹  Camille Dumon²  Suzanne M. Appleyard³  Gary A. Wayman³ 

[1] Aix-Marseille Univ UMR 1249, INSERM (Institut National de La Santé et de La Recherche Médicale) Unité 1249, INMED (Institut de Neurobiologie de La Méditerranée), Parc Scientifique de Luminy, Marseille, France;Aix-Marseille Univ UMR 1249, INSERM (Institut National de La Santé et de La Recherche Médicale) Unité 1249, INMED (Institut de Neurobiologie de La Méditerranée), Parc Scientifique de Luminy, Marseille, France;Neurochlore Parc Scientifique et Technologique de Luminy, Bâtiment Beret Delaage, Zone Luminy Entreprises Biotech, Marseille, France;Program in Neuroscience, Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA;

关键词: GABA;    KCC2;    Chloride homeostasis;    Hippocampus;    Rat;    Leptin;    Maternal obesity;   

DOI  :  10.1186/s13041-020-00689-z

来源: Springer

【 摘 要 】

The canonical physiological role of leptin is to regulate hunger and satiety acting on specific hypothalamic nuclei. Beyond this key metabolic function; leptin also regulates many aspects of development and functioning of neuronal hippocampal networks throughout life. Here we show that leptin controls chloride homeostasis in the developing rat hippocampus in vitro. The effect of leptin relies on the down-regulation of the potassium/chloride extruder KCC2 activity and is present during a restricted period of postnatal development. This study confirms and extends the role of leptin in the ontogenesis of functional GABAergic inhibition and helps understanding how abnormal levels of leptin may contribute to neurological disorders.

【 授权许可】

CC BY