Development of a clinical diagnostic tool to differentiate multiple myeloma from bone metastasis in patients with destructive bone lesions (MM-BM DDx)

BMC Family Practice

Jayanton Patumanond¹  Phichayut Phinyo²  Ekarat Rattarittamrong³  Titinat Maihom⁴  Areerak Phanphaisarn⁴  Pakorn Kerdsinchai⁴  Dumnoensun Pruksakorn⁵ 

[1] Center for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand;Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand;Center for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand;Musculoskeletal Science and Translational Research (MSTR), Chiang Mai University, Chiang Mai, Thailand;Department of Internal Medicine, Faculty of Medicine, Division of hematology, Chiang Mai University, Chiang Mai, Thailand;Musculoskeletal Science and Translational Research (MSTR), Chiang Mai University, Chiang Mai, Thailand;Musculoskeletal Science and Translational Research (MSTR), Chiang Mai University, Chiang Mai, Thailand;Biomedical Engineering Institute, Chiang Mai University, Chiang Mai, Thailand;Omics Center for Health Sciences (OCHS), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand;Department of Orthopedics, Faculty of Medicine, Orthopedic Laboratory and Research Network (OLARN), Chiang Mai University, Chiang Mai, Thailand;

关键词: Bone metastasis;    Diagnosis;    Multiple myeloma;    Osteolytic lesion;    Prediction;   

DOI  :  10.1186/s12875-020-01283-x

来源: Springer

【 摘 要 】

BackgroundMost patients with destructive bone lesions undergo a comprehensive diagnostic procedure to ensure that proper treatment decisions are pursued. For patients with multiple myeloma, this can lead to delays in diagnosis and treatment initiation. This study was conducted to develop a diagnostic rule that could serve as a tool for early identification of multiple myeloma and promote timely referral of patients to haematologists.MethodsThe clinical prediction rule was developed using a retrospective case-series of patients with multiple myeloma (MM) and those with bone metastasis (BM) at Chiang Mai University Hospital from 2012 to 2015. Multivariable fractional polynomial logistic regression was used to derive a diagnostic model to differentiate between MM and BM patients (MM-BM DDx).ResultsA total of 586 patients (136 MM patients and 450 BM patients) were included. Serum creatinine, serum globulin, and serum alkaline phosphatase were identified as significant indicators for the differentiation of MM and BM patients. The MM-BM DDx model showed excellent discriminative ability [AuROC of 0.90 (95%CI 0.86 to 0.93)] and good calibration.ConclusionsThis MM-BM DDx model could potentially allow for early myeloma diagnosis and improvement of overall prognosis. A prospective validation study is needed to confirm the accuracy of the MM-BM DDx model prior to its application in clinical practice.

【 授权许可】

CC BY