Synthesis of 99mtc(V)-DMSA and radiolabelling of SPIO nanoparticles

3rd Annual Applied Science and Engineering Conference

工业技术;自然科学

Sintya, E.^1

Faculty of Medicine and Health Sciences, Universitas Warmadewa Denpasar, Bali, Indonesia^1

关键词: Basic conditions;    Biomedical applications;    Bone metastasis;    Imaging agent;    Meso-2 ,3-dimercaptosuccinic acids;    Potential impacts;    Radiolabelling;    Superparamagnetic iron oxide nanoparticles;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/434/1/012152/pdf
DOI  :  10.1088/1757-899X/434/1/012152

来源: IOP

【 摘 要 】

99mTc(V)-DMSA has been approved to be a successful tumour -imaging agent in the many types of cancer such as medullary thyroid and bone metastases. 99mTc (V)-DMSA was successfully formed from labelling meso-2,3-dimercaptosuccinic acid (DMSA) with 99mTc which was done under basic conditions. In this experiment superparamagnetic iron oxide nanoparticles (SPIOs) labelling with 99mTc (V)-DMSA is being tested. These nanoparticles have been the most developed for biomedical applications due to their high stability and high biocompatibility. The results of this experiment show that combination between PEGylated SPIOs and 99mTc (V)-DMSA has a potential impact on increasing the quality of imaging cancers.