Superparamagnetic Gd- and Mn-substituted Magnetite Fluids Applied as MRI Contrast Agents

Bulletin of the Korean chemical society

Chang Hyun Lee¹  Jong Hee Kim¹  Sang Kuk Lee¹ 

关键词: Superparamagnetism;    Magnetic nanoparticle;    Imaging agent;    In vitro;    In vivo;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The experimental particle samples included (Mn_0.1Fe_0.9)OFe₂O₃ and FeO�?(Gd_0.1Fe_0.9)₂O₃ with Mn²⁺ and Gd³⁺ substitutions in inverse spinel Fe₃O₄. A lecithin surfactant was adsorbed onto the magnetic particles by ultrasonication. The samples prepared showed excellent dispersibility at the mean size of 13 nm; their saturation magnetization values were 63 emu/g for the bare and Mn-substituted magnetites, and 56 emu/g for the Gd-substituted magnetite. The crystal structure of the substituted magnetites was very similar to that of the bare magnetite, due to a small amount of 0.1 mole fraction substituted in synthesizing the magnetite. The magnetite fluids, according to T2-weighted MR images, effectively diminished the signal intensity in the liver and spleen of Sprague-Dawley rats.

【 授权许可】

Unknown