Nanoparticle-Loaded Polarized-Macrophages for Enhanced Tumor Targeting and Cell-Chemotherapy

Nano-Micro Letters

Shunli Fu¹  Teng Hou¹  Rui Yang¹  Na Zhang¹  Weiwei Mu¹  Shuang Liang¹  Zipeng Zhang¹  Yongjun Liu¹  Tianqi Wang¹  Tong Gao¹ 

[1] Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Wenhuaxi Road, 250012, Jinan, People’s Republic of China;

关键词: Polarized-macrophages;    Cell therapy;    Cell-mediated drug delivery;    Chemotherapy;    Lipid nanoparticles;   

DOI  :  10.1007/s40820-020-00531-0

来源: Springer

【 摘 要 】

tsA polarized-macrophages-based drug delivery system (M1/SLNP) was presented for the cell-chemotherapy of cancer.Polarized-macrophages were used both as therapeutic tool to provide immunotherapy and as delivery vessel to target deliver chemotherapeutic drugs to tumor tissues for chemotherapy simultaneously.M1/SLNP was a multifunctional delivery system with simple structure, excellent safety, and without complex synthesis process.

【 授权许可】

CC BY