Cell-mediated delivery of synthetic nano- and microparticles

JOURNAL OF CONTROLLED RELEASE

卷:259

Article

Klok, Harm-Anton¹ 

[1] Ecole Polytech Fed Lausanne, Inst Mat, Batiment MXD,Stn 12, CH-1015 Lausanne, Switzerland

关键词: Nano- and microparticles;    Cellular backpacks;    Cell surface-conjugation;    Cellular hitchhiking;    Cell-mediated drug delivery;   

DOI  :  10.1016/j.jconrel.2017.01.048

来源: Elsevier

【 摘 要 】

Cell mediated delivery of synthetic nano- and microparticle based drug carriers is a very promising strategy to enhance control over the distribution of drugs and improve targeting. This article will present an overview of work, which has been done to explore cell surface modification strategies for the cellular hitchhiking of synthetic nano-and microparticles. The first part of this article will present and discuss the different types of cells that have been explored for cell mediated drug delivery. The second part of this review will discuss the various chemical strategies that have been elaborated for the conjugation or immobilization of nano-and microparticles on the surface of these cells. (C) 2017 Elsevier B.V. All rights reserved.

【 授权许可】

Free