Environmental Sciences Europe | |
Target screening of plant secondary metabolites in river waters by liquid chromatography coupled to high-resolution mass spectrometry (LC–HRMS) | |
Barbara F. Günthardt1  Thomas D. Bucheli1  Carina D. Schönsee2  Martin Krauss3  Mulatu Yohannes Nanusha4  Werner Brack4  | |
[1] Agroscope, Environmental Analytics, Reckenholzstrasse 191, 8046, Zurich, Switzerland;Agroscope, Environmental Analytics, Reckenholzstrasse 191, 8046, Zurich, Switzerland;Department of Environmental Systems Science, ETH Zürich, Universitätsstraße 16, 8092, Zurich, Switzerland;Department of Effect-Directed Analysis, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318, Leipzig, Germany;Department of Effect-Directed Analysis, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318, Leipzig, Germany;Department of Evolutionary Ecology and Environmental Toxicology, Faculty of Biological Sciences, Goethe University Frankfurt, Max-von-Laue Str. 13, 60438, Frankfurt (Main), Germany; | |
关键词: Natural toxins; Bioactive compounds; Mixture toxicity; Surface water; Emerging contaminants; | |
DOI : 10.1186/s12302-020-00399-2 | |
来源: Springer | |
【 摘 要 】
BackgroundSubstantial efforts have been made to monitor potentially hazardous anthropogenic contaminants in surface waters while for plant secondary metabolites (PSMs) almost no data on occurrence in the water cycle are available. These metabolites enter river waters through various pathways such as leaching, surface run-off and rain sewers or input of litter from vegetation and might add to the biological activity of the chemical mixture. To reduce this data gap, we conducted a LC–HRMS target screening in river waters from two different catchments for 150 plant metabolites which were selected from a larger database considering their expected abundance in the vegetation, their potential mobility, persistence and toxicity in the water cycle and commercial availability of standards.ResultsThe screening revealed the presence of 12 out of 150 possibly toxic PSMs including coumarins (bergapten, scopoletin, fraxidin, esculetin and psoralen), a flavonoid (formononetin) and alkaloids (lycorine and narciclasine). The compounds narciclasine and lycorine were detected at concentrations up to 3 µg/L while esculetin and fraxidin occurred at concentrations above 1 µg/L. Nine compounds occurred at concentrations above 0.1 µg/L, the Threshold for Toxicological Concern (TTC) for non-genotoxic and non-endocrine disrupting chemicals in drinking water.ConclusionsOur study provides an overview of potentially biologically active PSMs in surface waters and recommends their consideration in monitoring and risk assessment of water resources. This is currently hampered by a lack of effect data including toxicity to aquatic organisms, endocrine disruption and genotoxicity and demands for involvement of these compounds in biotesting.
【 授权许可】
CC BY
【 预 览 】
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