Anopheline and human drivers of malaria risk in northern coastal, Ecuador: a pilot study

Malaria Journal

Bibiana E. Salazar-Costa¹  Iván Alejandro Saá Portilla¹  Fabián E. Saénz¹  Juan José Bustillos¹  Sofía Ocaña-Mayorga¹  Daniel J. English²  Neil F. Lobo²  James A. Martin²  Cristian Koepfli²  Allison L. Hendershot²  Madeline Woodruff²  Claudia A. Vera-Arias³ 

[1]Centro de Investigación Para La Salud en América Latina, Facultad de Ciencias Exactas Y Naturales, Pontificia Universidad Católica del Ecuador, Calle San Pedro Y Pambahacienda, 170530, Nayón, Ecuador

[2]Eck Institute for Global Health, University of Notre Dame, 46556, Notre Dame, IN, USA

[3]Eck Institute for Global Health, University of Notre Dame, 46556, Notre Dame, IN, USA

[4]Centro de Investigación Para La Salud en América Latina, Facultad de Ciencias Exactas Y Naturales, Pontificia Universidad Católica del Ecuador, Calle San Pedro Y Pambahacienda, 170530, Nayón, Ecuador

关键词: Nyssorhynchus albimanus;    Anopheles calderoni;    Plasmodium falciparum;    Bionomics;    Malaria;    Long-lasting insecticide-treated nets (LLINs);    Indoor residual spraying (IRS);    Human behaviour;    Ecuador;   

DOI  :  10.1186/s12936-020-03426-y

来源: Springer

【 摘 要 】

BackgroundUnderstanding local anopheline vector species and their bionomic traits, as well as related human factors, can help combat gaps in protection.MethodsIn San José de Chamanga, Esmeraldas, at the Ecuadorian Pacific coast, anopheline mosquitoes were sampled by both human landing collections (HLCs) and indoor-resting aspirations (IAs) and identified using both morphological and molecular methods. Human behaviour observations (HBOs) (including temporal location and bed net use) were documented during HLCs as well as through community surveys to determine exposure to mosquito bites. A cross-sectional evaluation of Plasmodium falciparum and Plasmodium vivax infections was conducted alongside a malaria questionnaire.ResultsAmong 222 anopheline specimens captured, based on molecular analysis, 218 were Nyssorhynchus albimanus, 3 Anopheles calderoni (n = 3), and one remains unidentified. Anopheline mean human-biting rate (HBR) outdoors was (13.69), and indoors (3.38) (p = 0.006). No anophelines were documented resting on walls during IAs. HBO-adjusted human landing rates suggested that the highest risk of being bitten was outdoors between 18.00 and 20.00 h. Human behaviour-adjusted biting rates suggest that overall, long-lasting insecticidal bed nets (LLINs) only protected against 13.2% of exposure to bites, with 86.8% of exposure during the night spent outside of bed net protection. The malaria survey found 2/398 individuals positive for asymptomatic P. falciparum infections. The questionnaire reported high (73.4%) bed net use, with low knowledge of malaria.ConclusionThe exophagic feeding of anopheline vectors in San Jose de Chamanga, when analysed in conjunction with human behaviour, indicates a clear gap in protection even with high LLIN coverage. The lack of indoor-resting anophelines suggests that indoor residual spraying (IRS) may have limited effect. The presence of asymptomatic infections implies the presence of a human reservoir that may maintain transmission.

【 授权许可】

CC BY