Synthesis of graphene quantum dots and their applications in drug delivery

Journal of Nanobiotechnology

Mohsen Mohammadniaei¹  Ming Zhang¹  Yifeng Fu²  Ya Liu²  Johan Liu³  Lilei Ye⁴  Nan Wang⁴  Qiqing Zhang⁵  Fan Wang⁵  Lu Li⁵  Xuebin Song⁵  Changhong Zhao⁶ 

[1] Department of Health Technology, Technical University of Denmark, 2800, Kongens Lyngby, Denmark;Electronics Materials and Systems Laboratory, Department of Microtechnology and Nanoscience, Chalmers University of Technology, 412 96, Gothenburg, Sweden;Electronics Materials and Systems Laboratory, Department of Microtechnology and Nanoscience, Chalmers University of Technology, 412 96, Gothenburg, Sweden;School of Automation and Mechanical Engineering, SMIT Center, Shanghai University, Box 808, No 20, Chengzhong Road, 201800, ShanghaiShanghai, China;SHT Smart High-Tech AB, 411 33, Gothenburg, Sweden;School of Life Sciences and Technology, Xinxiang Medical University, 453003, Xinxiang, P. R. China;School of Life Sciences and Technology, Xinxiang Medical University, 453003, Xinxiang, P. R. China;Electronics Materials and Systems Laboratory, Department of Microtechnology and Nanoscience, Chalmers University of Technology, 412 96, Gothenburg, Sweden;

关键词: Graphene quantum dots;    Top-down;    Bottom-up;    Drug delivery;    Delivery-release mode;   

DOI  :  10.1186/s12951-020-00698-z

来源: Springer

【 摘 要 】

This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.

【 授权许可】

CC BY