Correlations between chromobox homolog 8 and key factors of epithelial–mesenchymal transition in hepatocellular carcinoma

Cancer Cell International

Yuanyuan Fu¹  Shengkui Tan¹  Di Li¹  Chunhua Bei¹  Xiaonian Zhu¹  Juan Kong¹  Shidong Zhang¹  Wei Luo² 

[1] Department of Epidemiology and Health Statistics, School of Public Health, Guilin Medical University, 109 Huancheng North Road 2, 541004, Guilin, Guangxi, People’s Republic of China;Nanchong Central Hospital, The Second Clinical College of North Sichuan Medical College, 637000, Nanchong, Sichuan, People’s Republic of China;

关键词: Chromobox protein homolog 8;    Hepatocellular carcinoma;    Metastasis;    Epithelial mesenchymal transition;   

DOI  :  10.1186/s12935-019-1063-z

来源: Springer

【 摘 要 】

BackgroundHepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, especially in China, with high metastasis and poor prognosis. Recently, as the core component of the polycomb repressive complexes 1 (PRC1), chromobox protein homolog 8 (CBX8) is considered as an oncogene and prognostic marker in HCC.MethodsA tissue microarray of 166 paired HCC and adjacent non-tumor samples were collected to identify the relationship between CBX8 and epithelial mesenchymal transition (EMT) associated proteins by Spearman correlation analysis. Knock-down of CBX8 in HCC cells was conducted to detect the biologic functions of CBX8 in HCC metastasis.ResultsWe found out that CBX8 was over-expressed in HCC and its expression was closely related to the metastasis of HCC patients. In addition, knock-down of CBX8 was found to inhibit the invasion and migration ability of HCC cells. Moreover, there was a significant relationship between expression of CBX8 and EMT associated proteins both in HCC cells and tumor tissues.ConclusionsOur results indicate that CBX8 promotes metastasis of HCC by inducing EMT process.

【 授权许可】

CC BY