Shedding light on the role of keratinocyte-derived extracellular vesicles on skin-homing cells

Stem Cell Research & Therapy

Golara Nasiri¹  Aliakbar Alizadeh¹  Lobat Tayebi²  Negar Azarpira³  Sanaz Goshtasbi³ 

[1] Department of Tissue Engineering and Cell Therapy, School of Advanced Technologies in Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;Marquette University School of Dentistry, 53233, Milwaukee, WI, USA;Transplant Research Center, Shiraz University of Medical Sciences, Khalili Street, 7193711351, Shiraz, Iran;

关键词: Extracellular vesicles;    Keratinocytes;    Fibroblasts;    Melanocytes;    Immune cells;    Skin;   

DOI  :  10.1186/s13287-020-01929-8

来源: Springer

【 摘 要 】

Extracellular vesicles (EVs) are secretory lipid membranes with the ability to regulate cellular functions by exchanging biological components between different cells. Resident skin cells such as keratinocytes, fibroblasts, melanocytes, and inflammatory cells can secrete different types of EVs depending on their biological state. These vesicles can influence the physiological properties and pathological processes of skin, such as pigmentation, cutaneous immunity, and wound healing. Since keratinocytes constitute the majority of skin cells, secreted EVs from these cells may alter the pathophysiological behavior of other skin cells. This paper reviews the contents of keratinocyte-derived EVs and their impact on fibroblasts, melanocytes, and immune cells to provide an insight for better understanding of the pathophysiological mechanisms of skin disorders and their use in related therapeutic approaches.

【 授权许可】

CC BY