The role of postprandial very-low-density lipoprotein in the development of atrial remodeling in metabolic syndrome

Lipids in Health and Disease

Liang-Yin Ke¹  Hsiang-Chun Lee²  Shyi-Jang Shin³  Min-Fang Chao⁴  He-Jiun Jiang⁵  Yi-Hsiung Lin⁶  Yu-Hsun Lin⁶  Wei-Chung Tsai⁷  Ming-Yen Lin⁸  Jih-Kai Huang⁹ 

[1] Center for Lipid Biosciences, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;Lipid Science and Aging Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Center for Lipid Biosciences, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;Lipid Science and Aging Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Institute/Center of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan;Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Metabolism, Affiliated Hospital of Kaohsiung Medical University, Kaohsiung, Taiwan;College of Medicine, I-Shou University, Kaohsiung, Taiwan;Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;

关键词: Atrial cardiomyopathy;    Atrial fibrillation;    Metabolic syndrome;    Negatively charged;    Postprandial;    Very-low-density lipoprotein;   

DOI  :  10.1186/s12944-020-01386-5

来源: Springer

【 摘 要 】

BackgroundNegatively charged very-low-density lipoprotein (VLDL-χ) in metabolic syndrome (MetS) patients exerts cytotoxic effects on endothelial cells and atrial myocytes. Atrial cardiomyopathy, manifested by atrial remodeling with a dilated diameter, contributes to atrial fibrillation pathogenesis and predicts atrial fibrillation development. The correlation of VLDL-χ with atrial remodeling is unknown. This study investigated the association between VLDL-χ and remodeling of left atrium.MethodsConsecutively, 87 MetS and 80 non-MetS individuals between 23 and 74 years old (50.6% men) without overt cardiovascular diseases were included in the prospective cohort study. Blood samples were collected while fasting and postprandially (at 0.5, 1, 2, and 4 h after a unified meal). VLDL was isolated by ultracentrifugation; the percentile concentration of VLDL-χ (%) was determined by ultra-performance liquid chromatography. The correlations of left atrium diameter (LAD) with variables including VLDL-χ, LDL-C, HDL-C, triglycerides, glucose, and blood pressure, were analyzed by multiple linear regression models. A hierarchical linear model was conducted to test the independencies of each variable’s correlation with LAD.ResultsThe mean LAD was 3.4 ± 0.5 cm in non-MetS subjects and 3.9 ± 0.5 cm in MetS patients (P < 0.01). None of the fasting lipid profiles were associated with LAD. VLDL-χ, BMI, waist circumference, hip circumference, and blood pressure were positively correlated with LAD (all P < 0.05) after adjustment for age and sex. Significant interactions between VLDL-χ and blood pressure, waist circumference, and hip circumference were observed. When adjusted for obesity- and blood pressure-related variables, 2-h postprandial VLDL-χ (mean 1.30 ± 0.61%) showed a positive correlation with LAD in MetS patients. Each 1% VLDL-χ increase was estimated to increase LAD by 0.23 cm.ConclusionsPostprandial VLDL-χ is associated with atrial remodeling particularly in the MetS group. VLDL-χ is a novel biomarker and may be a therapeutic target for atrial cardiomyopathy in MetS patients.Trial registrationISRCTN 69295295. Retrospectively registered 9 June 2020.

【 授权许可】

CC BY