Obesity phenotypes and their relationships with atrial fibrillation

PeerJ

article

Szu-Ying Tsai¹  Hsin-Hao Chen³  Hsin-Yin Hsu²  Ming-Chieh Tsai⁶  Le-Yin Hsu⁷  Lee-Ching Hwang²  Kuo-Liong Chien⁷  Chien-Ju Lin³  Tzu-Lin Yeh³ 

[1] Department of Family Medicine, Taipei City Hospital, Zhongxing Branch;Department of Family Medicine, Taipei MacKay Memorial Hospital;Department of Family Medicine, Hsinchu MacKay Memorial Hospital, Hsinchu City;Department of Medicine, MacKay Medical College;MacKay Junior College of Medicine, Nursing, and Management;Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei MacKay Memorial Hospital;Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University;Department of Internal Medicine, National Taiwan University Hospital

关键词: Metabolically healthy obesity;    Metabolically unhealthy;    Metabolic obesity phenotypes;    Atrial fibrillation;    Metabolic syndrome;   

DOI  :  10.7717/peerj.12342

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Background This study assessed the associations of metabolic obesity phenotypes with the risk of atrial fibrillation (Afib). Methods This prospective cohort study categorized Taiwanese adults according to their body mass index (BMI) and metabolic health status at baseline. We assigned the participants to the underweight (BMI < 18.5 kg/m2), normal weight (BMI = 18.5–23.9 kg/m2), and overweight/obesity groups (BMI ≥ 24 kg/m2). Metabolically healthy was defined as absence of hypertension, diabetes, and hyperlipidemia and the presence of healthy metabolic profiles. Results In total, 5,742 adults were included. During a median follow-up of 13.7 years, 148 patients developed Afib. Compared to the metabolically healthy normal weight group, the risk of Afib was significantly higher than those in the metabolically unhealthy overweight/obesity (hazard ratio = 2.20, 95% confidence interval [1.12–4.33]) and metabolically unhealthy normal weight groups (HR = 2.64, 95% CI [1.34–5.17]). Additionally, the point estimate suggested a 1.97-fold greater risk among the metabolically healthy overweight/obesity group, although this difference was not significant given the wide confidence interval (HR = 1.97, 95% CI [0.80–4.86]). Conclusion Our results demonstrated the relationships of metabolic health and weight regarding the risk of Afib in Taiwanese adults. The Afib risk among metabolic and obesity phenotypes is associated with a metabolically unhealthy status. A trend toward a higher Afib risk with obesity among metabolically healthy subjects was observed. However, the result was not robust and it still suggested further study.

【 授权许可】

CC BY