In Situ Synthesis of Fluorescent Mesoporous Silica–Carbon Dot Nanohybrids Featuring Folate Receptor-Overexpressing Cancer Cell Targeting and Drug Delivery

Nano-Micro Letters

Zhongjun Li¹  Yuhui Wang²  Hengwei Lin²  Shan Sun²  Kai Jiang²  Shuai Zhao³  Qinghai Shu⁴  Song Wu⁵  Yu Liu⁵ 

[1] College of Chemistry and Molecular Engineering, Zhengzhou University, 450001, Zhengzhou, People’s Republic of China;Key Laboratory of Graphene Technologies and Applications of Zhejiang Province, Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, 315201, Ningbo, People’s Republic of China;School of Material Science and Engineering, Beijing Institute of Technology, 100081, Beijing, People’s Republic of China;Key Laboratory of Graphene Technologies and Applications of Zhejiang Province, Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, 315201, Ningbo, People’s Republic of China;School of Material Science and Engineering, Beijing Institute of Technology, 100081, Beijing, People’s Republic of China;The Affiliated Luohu Hospital of Shenzhen University, Shenzhen Luohu Hospital Group, 518001, Shenzhen, People’s Republic of China;The Affiliated Luohu Hospital of Shenzhen University, Shenzhen Luohu Hospital Group, 518001, Shenzhen, People’s Republic of China;

关键词: Mesoporous silica nanoparticles;    Carbon dots;    Fluorescence imaging;    Targeted drug delivery;    Chemotherapy;   

DOI  :  10.1007/s40820-019-0263-3

来源: Springer

【 摘 要 】

tsA one-pot method was developed for the preparation of fluorescent mesoporous silica nanoparticles–carbon dots (MSNs–CDs) nanohybrid.The MSNs–CDs nanohybrid showed stable and bright yellow emission, excellent biocompatibility, and specific targeting capability toward folate receptor-overexpressing cancer cells and can be applied as fluorescence imaging-guided drug carriers for effectively delivering anticancer drugs to tumor sites.

【 授权许可】

CC BY