The effect on the morphology of mesoporous silica nanopaticles modified with different functional groups

6th Annual International Conference on Material Science and Engineering

Wang, Youyun^1,2,3,4 ; Wang, Yu^1,2,3,4 ; Wang, Wanxia^1,2,3,4 ; Liu, Mingxing^1,2,3,4

Key Laboratory of Fermentation Engineering, Ministry of Education, China^1

Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, China^2

National 111 Center for Cellular Regulation and Molecular Pharmaceutics, China^3

Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan

430068, China^4

关键词: Drug delivery system;    Electron microscopies (TEM);    ITS applications;    Mesoporous Silica;    Mesoporous silica nanoparticles;    Mesoporous structures;    Nitrogen adsorption desorption;    Particle properties;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/397/1/012003/pdf
DOI  :  10.1088/1757-899X/397/1/012003

来源: IOP

【 摘 要 】

Three types of nanomaterials marked were successfully synthesized by grafting HA, HOOC-PEG-COOH and NH2-ZnO QDs on the surface of colloidal mesoporous silica nanoparticles modified with sulfydryl, amino and carboxyl groups, respectively, which could be marked as FRET-CMS, CMS-PEG-COOH and ZnO-CMS, respectively. Moreover, the structural and particle properties of these nanomaterials were characterized by dynamic light scattering(DLS), ransmission electron microscopy (TEM) and nitrogen adsorption-desorption measurements. These nanoparticles presented with a relatively uniform spherical shape morphology with a diameter of about 100 nm. Furthermore, the mesoporous structure of the nanoparticles still remain but the pore diameter would decreased slightly after encapsulated with diffierent functional groups, which would be no obvious effect on the capacity for the drug loading and releasing. So these results indicated that the properties of CMS nanoparticles with different functional groups were worth researching for its application in drug delivery system in the future.