Size-TunableMesoporous Silica for Macromolecular Drug Delivery

5th Annual International Conference on Material Engineering and Application

工业技术（总论）;材料科学

Wang, Yiyu^1^2 ; Niu, Chunqing^1^2 ; Gu, Jiamin^1^2 ; Hu, Chao^1^2 ; Wang, Youning^1^2 ; Zhang, Junhua^1^2^3

Hubei Key Laboratory of Quality Control of Characteristic Fruits and Vegetables, Hubei Engineering University, No. 272 Traffic Avenue, Xiaogan

432000, China^1

School of Life Science Technology, Hubei Engineering University, No. 272 Traffic Avenue, Xiaogan, Hubei Province

432000, China^2

State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology, Wuhan

430070, China^3

关键词: Different particle sizes;    Drug delivery carrier;    Dynamic light scattering technique;    Fourier transform infra red (FTIR) spectroscopy;    Macromolecular drugs;    Mesoporous Silica;    Narrow size distributions;    Sustained release;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/484/1/012006/pdf
DOI  :  10.1088/1757-899X/484/1/012006

来源: IOP

【 摘 要 】

A series of mesoporous silica nanospheres(MSNs)and different particle sizes rangingfrom about48 to 215nm has been successfully synthesized through modified base-catalyzed sol-gel method. The particle size distribution, structural and morphological of the samples were well characterized by dynamic light scattering technique (DLS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR),X-ray diffraction (XRD) and thermalgravimetry (TG). The results reveal that this MSNs exhibits good physicalproperties, including narrow size distribution,uniform pore texture in the nanospheres and good thermal stability. What's more, the size canbetuned by altering the concentration of aqueous ammonia in the silica precursor systems. The obtained MSNs are further used as a drug delivery carrier toinvestigate the in vitro drug release properties usingbovine serum albumin (BSA) as a macromolecularrepresentative model drug. It is found that this MSNsexhibit good obvious sustained release properties for macromolecular drug, suggesting its potential application in biological fields.