The therapeutic effect to eldecalcitol + bisphosphonate is superior to bisphosphonate alone in the treatment of osteoporosis: a meta-analysis

Journal of Orthopaedic Surgery and Research

Zaoqian Zheng¹  Jinyu Luo² 

[1] Department of Pharmacy, Tongde Hospital of Zhejiang Province, 310012, Hangzhou, Zhejiang, China;Division of Medical Administration, Tongde Hospital of Zhejiang Province, 310012, Hangzhou, Zhejiang, China;Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine, 310012, Hangzhou, Zhejiang, China;Hemopurification Center, Division of Nursing, Tongde Hospital of Zhejiang Province, No. 234 Gucui Road, Xihu District, 310012, Hangzhou, Zhejiang Province, China;

关键词: Osteoporosis;    Bisphosphonate;    Eldecalcitol;    Therapeutic effect;    Bone mineral density;    Meta-analysis;   

DOI  :  10.1186/s13018-020-01896-z

来源: Springer

【 摘 要 】

BackgroundOsteoporosis is a metabolic bone disease. Bisphosphonate (BP) and eldecalcitol (ELD) are two clinical first-line drugs for osteoporosis patients. However, the effect of ELD + BP vs. BP alone on osteoporosis treatment is still unclear. The present meta-analysis was conducted to evaluate the different therapeutic effect of BP + ELD vs. BP alone in osteoporosis treatment.MethodsEligible documents that selected from online databases including PubMed, Embase, and Cochrane Library were included in this study (updated to March 3, 2020). The quality assessment of the included studies was based on the guidelines of Cochrane. Meta-analysis was performed according to criteria such as intervention plan and outcome. The indicators including bone mineral density (BMD) in all enrolled studies were included in the current analysis. Pooled odds ratios (ORs) and weighted mean differences (WMDs) with 95% confidence intervals (CI) were calculated using fixed- or random-effects models. Then, heterogeneity analysis was performed based on Cochran’s Q test and I2 statistics.ResultsA total of 4 studies (456 cases) with high quality were enrolled in this study. The effect of ELD + BP was superior to BP alone based on indicators including femoral neck BMD (FN-BMD) and total hip BMD (TH-BMD) in patients with followed up ≤ 6 months. Moreover, the effect of ELD + BP was superior to BP alone based on lumbar spine BMD (LS-BMD) in patients with 12 months followed up.ConclusionTherapeutic effect of ELD + BP was superior to BP alone in osteoporotic patients based on the influence of BMD.

【 授权许可】

CC BY