Unexpected rapid increase in bone mineral density by bisphosphonate therapy after multiple spinal fractures: a case report

Journal of Medical Case Reports

Mikio Kamimura¹  Yukio Nakamura²  Jun Takahashi²  Hiroyuki Kato²  Hidefumi Koiwai³ 

[1] Center of Osteoporosis and Spinal Disorders, Kamimura Orthopedic Clinic;Department of Orthopaedic Surgery, Shinshu University School of Medicine;Koiwai Orthopedic Clinic;

关键词: Bone mineral density;    Bisphosphonate;    Osteoporosis;    Spinal fracture;   

DOI  :  10.1186/s13256-019-2219-0

来源: DOAJ

【 摘 要 】

Abstract Background Osteoporosis is a serious disease that causes bone fragility fractures and increases mortality. Bisphosphonates are the first-line drugs for osteoporosis. However, the gains in bone mineral density by use of bisphosphonates alone are limited. Case presentation We describe the clinical outcome of a Japanese woman with osteoporosis treated with bisphosphonates after multiple spinal fractures. After 3 years of treatment with the bisphosphonate alendronate, her lumbar bone mineral density and bilateral hip bone mineral density markedly increased by 61.9% and 32.5%, respectively. Conclusion We considered that our patient’s multiple fractures had caused a decrease in bone mineral density, which naturally improved with fracture healing to enhance the increase in bone mineral density with bisphosphonate treatment.

【 授权许可】

Unknown