Triorganotin as a compound with potential reproductive toxicity in mammals

Brazilian Journal of Medical and Biological Research

V.s. Delgado Filho¹  P.f.i. Lopes¹  P.l. Podratz¹  J.b. Graceli¹ 

[1] ,Universidade Federal do Espírito Santo Centro de Ciências da Saúde Departamento de MorfologiaVitória ES ,Brasil

关键词: Tributyltin;    Triphenyltin;    Endocrine disruptor;    Aromatase;    Imposex;    Mammalian reproductive organs;   

DOI  :  10.1590/S0100-879X2011007500110

来源: SciELO

【 摘 要 】

Organotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including humans and rodents. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme and other steroidogenic enzymes, affecting the reproductive capacity of male and female mammals. In this review, we discuss the cellular, biochemical, and molecular mechanisms by which triorganotin compounds induce adverse effects in the mammalian reproductive function.

【 授权许可】

CC BY   
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